The first recreational cannabis to be legally bought in Canada was purchased at midnight on Wednesday (02:30 GMT) on the eastern island of Newfoundland amid queues of hundreds of people.
Canada has become the second country after Uruguay to legalise possession and use of recreational cannabis.
Medical marijuana has been legal in the country since 2001.
But concerns remain, including about the readiness for police forces to tackle drug impaired driving.
Information has been sent to 15m households about the new laws and there are public awareness campaigns.
Ian Power, from the town of St John's began queuing at 20:00 local time so he could "make history". Newfoundland is half an hour ahead of the next province to the west.
"It's been my dream to be the first person to buy the first legal gram of cannabis in Canada, and here I finally am," he said.
Canadian provinces and municipalities have been preparing for months for the end of cannabis prohibition. They are responsible for setting out where cannabis can be bought and consumed.
This has created a patchwork of more or less restrictive legislation across the country.
How ready is Canada for legal cannabis?
There remain unanswered questions on some key issues around how legal cannabis will work in Canada.
A number of analysts are predicting a shortage of recreational marijuana in the first year of legalisation as production and licensing continues to ramp up to meet demand.
And the marketplace itself is still in its infancy.
Ontario, Canada's most populous province, will only begin opening retail stores next spring, though residents will be able to order cannabis online.
British Columbia, one of the provinces with the highest rates of cannabis use, will only have one legal store open on Wednesday.
Until retail locations are more widely available, some unlicensed cannabis retailers, which have flourished in the years since the law was first proposed, may stay open.
It is unclear if police will crack down on them immediately, or if they will turn a blind eye.
What's at stake?
Jessica Murphy, BBC News, Vancouver
Legal pot has been an inescapable topic for months in Canada, as governments and companies prepared in earnest for 17 October.
That day is finally here, and Canadians will learn just how much - or how little - the new framework will change the country. But this is not just a domestic affair.
With global trends shifting away from a strict prohibition of cannabis, the world will be watching this national experiment in drug liberalisation.
A measure of success - whether legalisation will be a win for Prime Minister Justin Trudeau ahead of the 2019 federal election - will depend on whether it meets his stated goals: restricting access of the drug to youth - who are among the heaviest users in Canada - reducing the burden of cannabis laws on the justice system, and undercutting the illicit market for the drug.
And if the outcomes are positive, other countries might just be more willing to follow suit.
Click here to read more: Canada legalises marijuana
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